A study of an allele sharing statistic on extended pedigrees
نویسندگان
چکیده
Linkage analysis using allele-sharing methods is a trait-model free approach to test for the location of a disease gene by studying the joint inheritance pattern of genes at different loci. For large pedigrees, the space of inheritance vectors becomes large and unavailability of data on individuals makes the probability computation of multilocus inheritance pattern almost infeasible. MCMC techniques provide a solution to this problem as they produce in real time a good estimate of the probabilities of inheritance vectors consistent with the data and the pedigree structure. The efficiency of Kruglyak et al. SpaiT$ statistic in detecting linkage is verified by applying MCMC technique to a dataset from a study on Alzheimer's disease in families of Volga-German ethnic origin. A permutation test tes:t-statilstlc for linkage. proposed to deal with the problem of standardizing the
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